FISH Analysis Test Menu

Fluorescence In Situ Hybridization (FISH) is a powerful molecular/cytogenetic technique that utilizes a fluorescent-labeled DNA probe to ascertain the presence or absence of a particular segment of DNA. It can be used to confirm or rule out small chromosome deletions, and to characterize subtle, complex chromosome rearrangements in interphase or metaphase cells.

Currently Genetics Center offers FISH analysis for the following microdeletion syndromes: Angelman syndrome, Prader-Willi syndrome, DiGeorge sequence, Velocardiofacial syndrome, Williams syndrome, Miller-Dieker syndrome and Smith-Magenis syndrome. We also perform whole chromosome painting for small translocations that cannot be visualized by conventional G-banding techniques.

The Genetics Center FISH laboratory is also equipped to test for many types of leukemia. We offer BCR/ABL testing for the Philadelphia chromosome (t(9;22)), which is found in about 99% of patients with CML. We offer testing for inv(16) which is found in 23% of AML-M4Eo patients. We also can detect the 15;17 translocation, which is found in about 97% of patients with APL.

If there is a test you require which is not listed, please contact us and speak to our laboratory personnel about available options.
 
 
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Congenital
Prenatal
Cancer



Congenital FISH testing
Cytogenetic Testing Requisition Form

  • 1p36 deletion syndrome
  • 4p16.3 (Wolf-hirschorn syndrome)
  • 5p15.2 (Cri du chat syndrome)
  • 7q11.23 (Williams syndrome)
  • 15q11-13 (Prader-Willi or Angelman syndrome)
  • 17p11.2 (Smith-Magenis syndrome)
  • 17p13.3 (Miller-Dieker syndrome)
  • Xp22.3 (STS or X-linked ichthyosis)
  • Sex Chromosomes
  • Yp11.3 (SRY)


Prenatal FISH testing
Cytogenetic Testing Requisition Form

  • Aneuploidy (13/21 and 18/X/Y)
  • Cep X/SRY (rarely)


B-cell Acute Lymphoblastic Leukemia (ALL)
Oncology Testing Requisition Form

  • t(9;22)
  • t(12;21)
  • 11q23
  • Cep 4, Cep 10, Cep 17


T-cell Acute Lymphoblastic Leukemia (ALL)
Oncology Testing Requisition Form

  • t(9;22)
  • 11q23
  • 9p21


Acute Myeloid Leukemia (AML)
Oncology Testing Requisition Form

  • +/- 5q
  • +/- 7q
  • inv(16)
  • t(8;21)
  • 11q23


Chronic Lymphocytic Leukemia (CLL)
Oncology Testing Requisition Form

  • 13q14.3/13q34/Cep12
  • 11q22.3/17p13.1


Chronic Myelogenic Leukemia (CML)
Oncology Testing Requisition Form

  • t(9;22)
  • Cep 8


Myelodysplastic Syndrome (MDS)
Oncology Testing Requisition Form

  • +/- 5q
  • +/- 7q
  • Cep 8
  • 20q12


Multiple Myeloma
Oncology Testing Requisition Form

  • 13q14.3/13q34/Cep12
  • 11q22.3/17p13.1
  • t(11;14)

Non-Hodgkin Lymphoma
Oncology Testing Requisition Form

  • t(11;14) (IGH/CCND1)
  • 3q27 (BCL 6)
  • 11q22.3/17p13.1 (p53)
  • t(14;18)

T-cell Lymphoma
Oncology Testing Requisition Form

  • +/- 7q
  • +8
  • 9p21
  • 11q23
  • 14q32


All Cancer FISH Probes
Oncology Testing Requisition Form

  • t(1;19) PBX1/TCF3
  • 2p23 ALK
  • Cep 4,10, 17
  • 5q31 EGR1
  • 7q31
  • Cep 8
  • 8q24 MYC
  • t(8;14) MYC/IGH
  • t(8;21) ETO/AML1
  • 9p21 gene name p16
  • t(9;22) BCR/ABL1
  • 11q23 MLL
  • t(11;14) CCND1/IGH
  • t(12;21) TEL/AML1 or ETV6/RUNX1
  • 13q14.3/13q34/Cep12 (CLL or Multiple Myeloma panel)
  • 13q14 FKHR
  • t(14;18) IGH/BCL2
  • t(15;17) PML/RARA
  • inv(16)
  • 17p13.1/11q22.3 (CLL or Multiple Myeloma panel)
  • 18q11.2 SYT
  • 20q12
  • 22q12 EWSR1
  • Cep X / SRY (bone marrow engraphment–rare)